Livedoid vasculitis - Ливедоидный Васкулит
Ливедоидный Васкулит (Livedoid vasculitis) — хроническое кожное заболевание, встречающееся преимущественно у женщин молодого и среднего возраста. Для описания его особенностей используется одна аббревиатура: «Болезненные пурпурные язвы с сетчатым рисунком нижних конечностей» (ФИОЛЕТОВЫЙ). Это связано с рядом заболеваний, включая хроническую венозную гипертензию и варикозное расширение вен.
☆ По результатам Stiftung Warentest 2022 года в Германии удовлетворенность потребителей ModelDerm была лишь немного ниже, чем платными телемедицинскими консультациями.
Это может сопровождаться болью.
References
Livedoid vasculopathy — редкое заболевание кожи, характеризующееся болезненными язвами, которые постоянно появляются на голенях.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy — редкое заболевание кожи, вызывающее рецидивирующие язвы на голенях, оставляющие после себя бледные шрамы, известные как «белая атрофия». Хотя точная причина до сих пор неясна, считается, что основным фактором является повышенная свертываемость крови (hypercoagulability) , а воспаление играет второстепенную роль. К факторам, способствующим свертыванию крови, относятся следующие - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. При биопсии заболевание показывает наличие тромбов внутри сосудов, утолщение стенок сосудов и рубцевание. Лечение включает в себя многосторонний подход, направленный на предотвращение образования тромбов с помощью таких лекарств, как антитромбоцитарные препараты, препараты, разжижающие кровь, и фибринолитическая терапия. При этом заболевании кожи можно использовать различные препараты — colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy — редкое заболевание, при котором поражения возникают на обеих ногах. Считается, что образование тромбов в крошечных кровеносных сосудах вызвано повышенным свертыванием крови и уменьшением разрушения тромбов, а также повреждением слизистой оболочки сосудов. Это чаще встречается у женщин, особенно в возрасте от 15 до 50 лет. Отказ от курения, уход за ранами и использование таких лекарств, как разжижители крови и антиагреганты, оказались эффективными.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
